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Although more than 400 blood groups have been identified, the ABO blood group system remains the most important in clinical medicine because :
It was the first blood group system to be discovered.
It has four different blood groups A, B, AB, O (H).
ABO(H) antigens are present in most body tissues and fluids.
ABO(H) antibodies are invariably present in plasma when persons RBC lacks the corresponding antigen.
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