A 50-year-old male presented with a characteristic lesion on the face for 5 years which is slowly increasing in size and bleeds whenever it is scratched. Patient has a history of chronic sun exposure. There is no evidence of pain or itching over the lesion Biopsy from the lesion. Which of the following drugs are approved for the above condition: - 1. 5-FU 2. Imiquimod 3. Itraconazole 4. Azathioprine 5. Vismodegib