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4729 Pathology

A four year old boy was admitted with a history of abdominal pain and fever for two months maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination liver and spleen were enlarged 4 cm and 3 cm respectivley below the costal margin. His hemoglobin was 10.0 g/dl, platelet count 3.7 x 1091L and total leukocyte count 70 x 109/L, which included 80% eosinophils Bone marrow examination revealed a cellular marrow comprising of 45% blasts and 34% Eosinophils and eosinophil precursors. The blasts stained negative for my eloperoxidase and nonspecific esterase and were positive for CD19, CD10, CD22 and CD20. Which one of the following statements is not true about disease?

AEosinophils are not pa of the Neoplastic clone
Bt (5:14) rearrangement may be detected in blasts
CPeripheral blood eosinophilia may normalize with chemotherapy
DInv (16) is often detected in the blasts and the eosinophils
Pathology
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