False statement about amyloidosis is
**Amyloidosis Core Concept**
Amyloidosis refers to a group of disorders characterized by the deposition of insoluble amyloid fibrils in various tissues and organs, leading to disruption of normal tissue architecture and function. This condition can result from the accumulation of various types of amyloid proteins, including immunoglobulin light chains, transthyretin, and beta-2 microglobulin.
**Why the Correct Answer is Right**
Amyloid fibrils are formed through a process known as misfolding, where normally soluble proteins aggregate and become insoluble, leading to the deposition of amyloid fibrils in tissues. The deposition of amyloid fibrils can disrupt normal tissue function, leading to a range of clinical manifestations depending on the location and type of amyloid deposits. In the case of systemic amyloidosis, amyloid deposits can be found in multiple organs, including the heart, kidneys, liver, and nervous system.
**Why Each Wrong Option is Incorrect**
**Option A:** This statement is incorrect because amyloidosis is indeed a genetic disorder in some cases, such as familial amyloid polyneuropathy caused by mutations in the transthyretin gene. However, not all amyloidosis is genetic.
**Option B:** This statement is incorrect because amyloidosis is characterized by the deposition of insoluble amyloid fibrils, not soluble proteins. Soluble proteins are typically cleared by the body through normal physiological processes.
**Option C:** This statement is incorrect because amyloidosis can indeed affect multiple organs, including the heart, kidneys, liver, and nervous system. Systemic amyloidosis is a condition where amyloid deposits are found in multiple organs.
**Clinical Pearl / High-Yield Fact**
One key point to remember is that amyloidosis can be caused by a range of factors, including genetic mutations, infections, and chronic diseases. The clinical manifestations of amyloidosis depend on the location and type of amyloid deposits, and a thorough medical history and physical examination are essential for making a diagnosis.
**Correct Answer: D.**