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4721 Pathology

A patient with chest pain was brought to the hospital. He was diagnosed to be a case of myocardial infarction and was administered a thrombolytic immediately. However, his cardiac condition worsened and he died. He was diagnosed to be suffering from “cardiac reperfusion injury”. Which of the following is an expected histological finding in his cardiac tissue?

APresence of coagulative necrosis with neutrophilic infiltration
BDeposition of granulation tissue
CPresence of contraction bands
DFibrosis and scar formation
Pathology
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4723 Pathology

A 4-year-old boy is brought to the physician by his parents because he tires easily. Physical examination reveals weakness in the pelvic and shoulder girdles and enlargement of the child’s calf muscle. Serum levels of creatine kinase are elevated. A biopsy of calf muscle shows marked variation in size and shape of muscle fibers. There are foci of muscle fiber necrosis, with myophagocytosis, regenerating fibers, and fibrosis. Molecular diagnostic assays would most likely show alterations in the length of the primary transcript for which of the following muscle-associated proteins?

AActin
BDesmin
CDystrophin
DGlycogen phosphorylase
Pathology
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