30 mg of ?-carotene daily. Hypothyroid patients are particularly susceptible to the development of carotenemia due to impaired breakdown of carotene to vitamin A. Reduction of carotenes from the diet results in the disappearance of skin yellowing and carotenemia over a period of 30-60 days.Human teratogenic drugsDrugAbnormalityThalidomidePhocomelia, Multiple defectsAnticancer drugs (methotrexate)Cleft palate, hydrocephalus, multiple defects, foetal deathAndrogensVirilization; limb, esophageal, cardiac defectsProgestinsVirilization of female foetusStiboestrolVaginal carcinoma in teenage female offspringTetracyclinesDiscoloured and deformed teeth, retarded bone growthWarfarinDepressed nose; eye and hand defects, growth retardationPhenytoinHypoplastic phalanges, sleft lip/palate, microcephalyPheenobarbitoneVariousmalformationsCarbamazepineNeural tube defects, other abnormalitiesValproate sodSpina bifida and other neural tube defectsAlcoholLow IQ baby, growth retardation, foetal alcohol syndromeACE inhibitorsHypoplasia of organs, growth retardation, foetal lossLithiumFoetal goiter, cardiac and other abnormalitiesAntithyroid drugsFoetal goiter and hypothyroidismIndomethacin/aspirinPremature closure of ductus arteriosusIsotretinoinCraniofacial, heart and CNS defects.">