DOPA (HYDROXYLATION)- DOPA=> Dopamine (DECARBOXYLATION)- Dopamine=> Norepinephrine (HYDROXYLATION)- Norepinephrine=> Epinephrine (METHYLATION)# This latter reaction is one of several in the body that uses SAM (S-adenosylhomocysteine) as a methyl donor.ReceptorEffectively bindsEffect of ligand bindingAlpha-1Epinephrine, NorepinephrineIncreased free calciumAlpha-2Epinephrine, NorepinephrineDecreased cyclic AMPBeta-1Epinephrine, NorepinephrineIncreased cyclic AMPBeta-2EpinephrineIncreased cyclic AMP">