Acute osteomyelitis typically affects children, especially in the metaphysis, presenting with severe pain, fever, and localized tenderness. It is most commonly seen in the long bones of the legs. The epiphyseal plate is a growth plate, not involved in acute osteomyelitis; infections usually affect the metaphysis, not the epiphyseal plate. While antibiotics are essential, treatment duration is usually 4–6 weeks, but the epiphyseal plate is not a site of involvement. The statement that it "involves epiphyseal plate" is false and thus the exception.

**✓ Correct: C. Involves Epiphyseal plate**