Acute osteomyelitis typically affects children, especially in the metaphysis, due to hematogenous spread. It presents with severe pain, fever, and local tenderness. The epiphyseal plate is not involved in acute osteomyelitis; it is more commonly affected in **septic arthritis** or **growth plate injuries**. Treatment involves prolonged antibiotic therapy, usually 4–6 weeks, depending on the causative organism and response. Involvement of the epiphyseal plate is a key misconception—this structure is not a site of acute osteomyelitis.

**✓ Correct: C. Involves Epiphyseal plate**