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Pharmacology
Methicillin-resistant staphylococci do not respond to β–lactam antibiotics because :
They produce a β–lactamase which destroys methicillin and related drugs
They elaborate an amidase which destroys methicillin and related drugs
They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics
They are less permeable to β-lactam antibiotics
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