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Pharmacology
Why is a combination of Ranitidine and Sucralfate better avoided in patient with peptic ulcer disease?
Ranitidine combines with sucralfate and prevents its action
Sucralfate inhibits ranitidine absorption
Ranitidine increases the gastric pH so sucralfate is not able to act
Combination of these two drugs produces serious side effects like agranulacytosis
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