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Pharmacology
All of the following are true about HMG CoA reductase inhibitors except:
CNS accumulation of simvastatin and lovastatin is high and less for pravastatin and fluvastatin
Simvastatin is rapidly and pravastatin is least metabolized.
Bioavailability is minimally modified when pravastatin is taken with food
Fibrinogen levels are increased by pravastatin
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