Used for acute mania as well as bipolar illness. Valproate --> Paicularly useful for rapid cyclers. o Atypical antipsychotics --> Olanzapine, risperidone, aripiprazole or quetiapine with or without benzodiazepine is the treatment of choice for acute mania. o Lamotrigine ---> Useful in rapidcycling bipolar depression. o Topiramiate and Gapapentin have shown some prophylactic effect in bipolar disorder. Remember o DOC for prophylaxis in bipolar disorder --> Lithium o DOC for acute mania --> Olanzapine or other atypical antipsychotics with or without BZDs.">