Soft coicosteroids have high topical : systemic activity ratio. "Ciclesonide and loteprednol etabonate are examples of soft steroids that are designed for delivery near to their site of action to exe their effect, and then undergo metabolism to inactive metabolites". -- Veterinary pharmacology & therapeutics Ciclesonide is used in bronchial asthma & COPD. It is a prodrug that is cleaved by esterase in the bronchial epithelium to release active moiety. o Loteprednol etabonate is used for ophthalmic disorders.">