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Pharmacology
Two antihistaminics terfenadine and astemizole were withdrawn from the market following the occurrence of cardiac arrhythmias when they were present in high levels in the blood. These effects were explained by the fact:
Use of these drugs by addicts
Genetic predisposition to metabolize succinylcholine slowly
Concurrent treatment with phenobarbital
Treatment of these patients with erythromycin, a macrolide antibiotic
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