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Pathology
A one year old boy presented with hepatosplenomegaly and delayed milestones. The liver biopsy and bone marrow biopsy revealed presence of histiocytes with PAS-positive Diastase-resistant material in the cytoplasm. Electron-microscopic examination of these histiocytes is most likely to reveal the presence of:
Birbeck's granules in the cytoplasm
Myelin figures in the cytoplasm
Parallel rays of tubular structures in lysosomes
Electron dense deposit in the mitochondria
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