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Pathology
A 55-year-old man presents with a solitary breast mass and biopsy reveals malignant cells. Immunohistochemical staining experiments show that the tumor cells are positive for HER2/neu and cytokeratins 4 and 11 and negative for estrogen receptors. Which of the following is thought to play a role in the development of cancer in the patient?
BRCA2 mutation
Chronic alcoholism
Gynecomastia
Hyperestrinism
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