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Microbiology
7. A 2 yr old boy presents with recurrent bacterial infections and Pneumocystis jiroveci pneumonia. Labs show markedly elevated IgM and low IgG. Which of the following is the most likely cause of his illness?
Autosomal- dominant mutation in the STAT3 gene
Deficiency in CD40 ligand or CD40
Defect in the NADPH oxidative pathway
Defective cytokine signaling in Tcell precursors
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