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Microbiology
There has been much speculation on the pathogenesis of group B streptococcal disease in the neonate. One of the most likely pathogenic mechanisms is
Complement C5a, a potent chemoattractant, activates PMNs
The streptococci are resistant to penicillin
The alternative complement pathway is activated
In the absence of specific antibody, opsonization, phagocyte recognition, and killing do not proceed normally
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