1 months), fatigue, weight loss and diarrhoea. After a variable period, serious opportunistic infections, secondary neoplasms or clinical neurological disease (grouped under the rubric AIDS indicator disease, discussed below), supervene and the patient is said to have developed AIDS. It should be evident from our discussion that in each of the three phases of HIV infection, viral replication continues to occur . Even in the chronic phase, before the severe decline in CD4+ cell count and the development of AIDS, there is extensive turnover of the virus. In other words HIV infection lacks a phase of true microbiologic latency, thus it is a phase during which all the HIV is in the form of proviral DNA and no cell is productively infected.">