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Anatomy
A 5-day-old male infant is diagnosed with Hirschsprung disease. CT scan examination reveals an abnormally dilated colon. Which of the following is the most likely embryologic mechanism responsible for Hirschsprung disease?
Failure of neural crest cells to migrate into the walls of the colon
Incomplete separation of the cloaca
Failure of recanalization of the colon
Defective rotation of the hindgut
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