Pathology Which of the following is not true regarding super-antigens- A Bind T cells irrespective of antigen specificity of TCR B Bind directly to both MHC II and T cell receptor causing T cell activation C Bind to cleft (or antigen binding groove) in the MHC H molecule D Binds directly to lateral aspect of T cell receptor 💡 Explanation Which of the following is not true regarding super-antigens- ✓ Correct Answer: C. Bind to cleft (or antigen binding groove) in the MHC H molecule