Side effects of cisplatin include all of the following EXCEPT:
**Core Concept**
Cisplatin is a platinum-based chemotherapy drug used to treat various types of cancers. Its side effects are primarily related to its mechanism of action, which involves forming platinum-DNA adducts, leading to DNA damage and cell death.
**Why the Correct Answer is Right**
Cisplatin is known for its nephrotoxicity, which is caused by the accumulation of platinum in the renal tubules, leading to tubular necrosis and acute kidney injury. Additionally, cisplatin can cause ototoxicity, particularly high-frequency hearing loss, due to the damage to the hair cells in the cochlea. Furthermore, cisplatin-induced peripheral neuropathy is a well-documented side effect, resulting from the damage to the dorsal root ganglia and the subsequent disruption of nerve conduction.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as cisplatin does not typically cause hypothyroidism. The drug can affect thyroid function, but this is not a common side effect.
**Option B:** This option is incorrect as cisplatin does not typically cause weight gain. The drug can cause nausea, vomiting, and anorexia, leading to weight loss.
**Option C:** This option is incorrect as cisplatin does not typically cause photosensitivity. The drug can cause skin rash, but this is not related to photosensitivity.
**Clinical Pearl / High-Yield Fact**
To minimize nephrotoxicity, it is essential to ensure adequate hydration and use of loop diuretics in patients receiving cisplatin. Additionally, the use of nephroprotective agents, such as amifostine, may help reduce the risk of renal toxicity.
**Correct Answer: C.**