Which of the following is considered as a high-risk susceptibility gene for malignant melanoma?
Correct Answer: CDKN2A
Description: Ans. B. CDKN2AThe cyclin-dependent kinase (CDK) inhibitor 2A gene (CDKN2A), located on chromosome 9p21, is the best-established high-risk locus for melanoma susceptibility.* In melanoma, tumor suppressors that play a protective role against melanoma are mutated.* CDKN2A encodes via alternative splicing for two proteins involved in cell cycle regulation: pl6/Ink4a and pl4/Arf, both act as tumor suppressors through the Rb and p53 cancer pathways, respectively.* CDKN2A mutations are found in approximately 40% of individuals with familial melanoma.
Category:
Skin
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now