Skin Which is the following is the main cytokine involved in erythema nodosum leprosum (ENL) reaction? A InterLeukin-2 B Interferon-gamma C Tumor necrosis factor-alpha D Macrophage colony stimulating factor 💡 Explanation Which is the following is the main cytokine involved in erythema nodosum leprosum (ENL) reaction? ✓ Correct Answer: C. Tumor necrosis factor-alpha