Which vaccine can cause adverse effects in persons with allergy to egg –
**Core Concept**
The question tests knowledge of vaccine-induced allergic reactions, specifically the association between egg allergy and certain vaccines. Egg allergy is a common concern in the administration of influenza and yellow fever vaccines, which contain egg proteins.
**Why the Correct Answer is Right**
The correct answer is related to the influenza vaccine, which is produced in chicken eggs and contains egg proteins. Individuals with egg allergy may experience severe allergic reactions, including anaphylaxis, after receiving the influenza vaccine. This is because their immune system mistakenly identifies the egg proteins in the vaccine as a threat, triggering an allergic response. The vaccine contains residual egg proteins from the manufacturing process, making it a potential allergen for individuals with egg allergy.
**Why Each Wrong Option is Incorrect**
**Option A:** Yellow fever vaccine - While it's true that the yellow fever vaccine is also produced in chicken eggs, it's not the most commonly associated vaccine with egg allergy. The yellow fever vaccine is still a potential allergen, but the question seems to be testing knowledge of the influenza vaccine specifically.
**Option B:** MMR vaccine - The MMR vaccine is not associated with egg allergy. It's a live attenuated vaccine produced in chick embryo tissue culture, not eggs.
**Option C:** HPV vaccine - The HPV vaccine is produced using recombinant DNA technology and is not associated with egg allergy.
**Clinical Pearl / High-Yield Fact**
Individuals with a history of egg allergy should be screened for allergy to egg proteins before receiving the influenza vaccine. In some cases, it may be safe to administer the vaccine under close medical supervision, but this should only be done after thorough evaluation and discussion with the patient.
**Correct Answer:** A. Influenza vaccine