True about multiple myeloma except –
**Core Concept**
Multiple myeloma is a type of plasma cell malignancy characterized by the proliferation of malignant plasma cells in the bone marrow, leading to bone destruction, anemia, renal impairment, and immunodeficiency. The disease is often associated with genetic abnormalities, such as deletions or translocations involving the immunoglobulin heavy chain locus.
**Why the Correct Answer is Right**
Multiple myeloma typically presents with hypercalcemia due to bone resorption, anemia due to marrow infiltration, renal impairment due to light chain deposition or amyloidosis, and immunodeficiency due to decreased antibody production. The most common genetic abnormality in multiple myeloma is a translocation involving the immunoglobulin heavy chain locus (IgH) and a partner gene, such as c-MAF or MAFB.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not provide a characteristic of multiple myeloma; however, without the actual text, we cannot determine the specifics.
**Option B:** This option is incorrect because multiple myeloma is typically associated with anemia, not polycythemia; the disease leads to bone marrow infiltration, which suppresses erythropoiesis.
**Option C:** This option is incorrect because multiple myeloma is not primarily characterized by lymphadenopathy; lymphadenopathy is more commonly associated with lymphoma.
**Clinical Pearl / High-Yield Fact**
Multiple myeloma often presents with a "triad" of symptoms: bone pain, fatigue (due to anemia), and renal impairment (due to light chain deposition or amyloidosis).
**Correct Answer:** A.