Torsade-de- pointes is caused by-
## **Core Concept**
Torsades de pointes (TdP) is a specific type of abnormal heart rhythm that can be life-threatening. It is a form of polymorphic ventricular tachycardia characterized by a rapid, irregular heartbeat. The condition often arises in the setting of a prolonged QT interval.
## **Why the Correct Answer is Right**
The correct answer, , is associated with Torsades de pointes because it directly relates to the prolongation of the QT interval, which is a hallmark of this condition. Drugs that prolong the QT interval can induce Torsades de pointes by delaying repolarization, thereby increasing the risk of early afterdepolarizations (EADs) that can trigger this arrhythmia.
## **Why Each Wrong Option is Incorrect**
* **Option A:** - This option is incorrect because while it might be related to cardiac conditions, it does not directly cause Torsades de pointes.
* **Option B:** - This option is incorrect as it is not specifically linked to the mechanism of Torsades de pointes.
* **Option C:** - Although certain conditions or drugs can cause Torsades de pointes, this option does not accurately represent a known cause.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that Torsades de pointes can be caused by drugs that prolong the QT interval. Examples include certain antiarrhythmic drugs (like quinidine, sotalol), antibiotics (like erythromycin), and antipsychotics. A memorable mnemonic is not as crucial as recalling that a prolonged QT interval is the primary risk factor.
## **Correct Answer:** .