Psychiatry The tricyclic antidepressant with LEAST autonomic and cardiotoxic effects: March 2004 A Amitriptyline B Desipramine C Lofepramine D Protriptyline 💡 Explanation The tricyclic antidepressant with LEAST autonomic and cardiotoxic effects: March 2004 ✓ Correct Answer: C. Lofepramine