Tear drop cell together with leukoerythroblast seen in ?
**Core Concept**
Tear drop cells are abnormally shaped red blood cells that are typically associated with myelofibrosis and other bone marrow disorders. These cells are characterized by their elongated, teardrop shape, which is caused by their passage through a fibrotic or hypocellular marrow space. Leukoerythroblastosis is a condition where both immature white blood cells (leukocytes) and immature red blood cells (erythrocytes) are present in the peripheral blood.
**Why the Correct Answer is Right**
Tear drop cells and leukoerythroblastosis are often seen in conditions that lead to bone marrow fibrosis or infiltration, such as myelofibrosis. In these conditions, the bone marrow is replaced by fibrotic tissue, which causes the red blood cells to take on an abnormal shape as they attempt to pass through the marrow space. The presence of leukoerythroblastosis indicates that the bone marrow is also producing immature white blood cells, which is a hallmark of myelofibrosis and other marrow disorders.
**Why Each Wrong Option is Incorrect**
* **Option A:** Tear drop cells and leukoerythroblastosis are not typically seen in conditions that primarily affect the spleen, such as splenic sequestration or hypersplenism.
* **Option B:** While anemia and thrombocytopenia can be seen in myelofibrosis, they are not the primary association with tear drop cells and leukoerythroblastosis.
* **Option C:** Tear drop cells and leukoerythroblastosis are not primarily seen in conditions that affect the lungs, such as pulmonary embolism or chronic obstructive pulmonary disease (COPD).
**Clinical Pearl / High-Yield Fact**
Tear drop cells and leukoerythroblastosis are often seen in myelofibrosis, a condition that is characterized by the replacement of bone marrow with fibrotic tissue. This condition can lead to anemia, thrombocytopenia, and other complications.
**Correct Answer: C.** Myelofibrosis