**Core Concept**
MHC (Major Histocompatibility Complex) restriction refers to the phenomenon where T cells recognize antigens only when they are presented by MHC molecules on the surface of antigen-presenting cells (APCs). This is a crucial aspect of the immune system, particularly in the context of cell-mediated immunity.

**Why the Correct Answer is Right**
MHC restriction is a fundamental principle in immunology, ensuring that T cells only respond to antigens presented by self-MHC molecules, thereby preventing autoimmune responses. The MHC molecules are essential for the recognition of peptide antigens by T cell receptors (TCRs) on CD4+ and CD8+ T cells. The interaction between the TCR and the MHC-peptide complex is highly specific, and it is this specificity that underlies MHC restriction.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because MHC restriction is indeed a part of the immune response, particularly in the context of cell-mediated immunity, where T cells play a central role.
**Option B:** This option is incorrect because MHC restriction is not a characteristic of humoral immunity, which involves the activation of B cells and the production of antibodies. Humoral immunity does not require MHC presentation for antigen recognition.
**Option C:** This option is incorrect because MHC restriction is not a feature of innate immunity, which provides immediate defense against pathogens. Innate immunity does not involve the activation of T cells or the recognition of antigens through MHC molecules.

**Clinical Pearl / High-Yield Fact**
MHC restriction is a critical aspect of immunology that helps prevent autoimmune responses by ensuring that T cells only respond to antigens presented by self-MHC molecules. This concept is essential for understanding various immune-related disorders, including autoimmune diseases and transplant rejection.

**Correct Answer: B. Humoral immunity does not require MHC presentation for antigen recognition.**