The part of sequence of RNA coding for a protein and it’s mutated sequence is given below. Normal sequence : AGC- GCC- GAA- AGA- AAG- AUG- ACG Mutated sequence : AGC- GCC- GAA- UGA- AAG- AUG- ACG Type of mutation shown above is

**Core Concept**
The given sequences represent the nucleotide bases in a RNA molecule, which ultimately code for a protein. This question requires the identification of a specific type of mutation, which is a change in the DNA or RNA sequence.

**Why the Correct Answer is Right**
The normal sequence codes for a protein, and the mutated sequence has a change from AGA to UGA. UGA is a stop codon, which signals the termination of protein synthesis. This change results in a premature stop codon, leading to a truncated protein product. This type of mutation is known as a nonsense mutation, which occurs when a point mutation changes a codon to a premature stop codon.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided, so we will move to the next one.
* **Option B:** This option is not provided, so we will move to the next one.
* **Option C:** This option is not provided, so we will move to the next one.
* **Option D:** This option is not provided, but since the correct answer is . , we will not discuss this option.

**Clinical Pearl / High-Yield Fact**
Nonsense mutations can lead to a variety of diseases, including genetic disorders such as sickle cell anemia and cystic fibrosis. These mutations can also lead to cancer, as they can result in the production of abnormal proteins that can have oncogenic properties.

**Correct Answer:** B. Nonsense mutation

✓ Correct Answer: B. Nonsense mutation