**Core Concept**
Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to dry eyes and dry mouth. It primarily affects lacrimal and salivary glands, resulting in impaired secretion of tears and saliva.

**Why the Correct Answer is Right**
Epiphora, which is the excessive tearing due to obstruction of the lacrimal system, is not a feature of Sjögren's syndrome. In fact, patients typically present with **keratoconjunctivitis sicca** due to reduced tear production. The condition is **autoimmune in nature**, with lymphocytic infiltration of salivary and lacrimal glands. Rheumatoid arthritis is a comorbid condition in some patients, but it is not a defining feature. Thus, epiphora contradicts the clinical picture of Sjögren’s.

**Why Each Wrong Option is Incorrect**
Option A: Keratoconjunctivitis sicca is a hallmark of Sjögren’s due to deficient tear production.
Option B: Rheumatoid arthritis can coexist, though it is not a feature of Sjögren’s itself.
Option D: The disease is fundamentally autoimmune, driven by autoantibodies like anti-SSA and anti-SSB.

**Clinical Pearl / High-Yield Fact**
Always remember: Sjögren’s causes **dry eyes and dry mouth**, not excess tears. Epiphora is a sign of **lacrimal duct obstruction**, not Sjögren’s.

✓ Correct Answer: C. Epiphora