**Core Concept**
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and degeneration of the joints, primarily affecting the hands and feet. The disease is mediated by autoantibodies, specifically rheumatoid factor (RF), and is associated with systemic inflammation.

**Why the Correct Answer is Right**
Rheumatoid arthritis is characterized by symmetric polyarthritis, morning stiffness lasting more than an hour, and systemic symptoms such as fever, weight loss, and fatigue. The disease often involves the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints, leading to joint deformities and functional impairment. The presence of rheumatoid nodules, a hallmark of RA, is another distinguishing feature.

**Why Each Wrong Option is Incorrect**
**Option A:** Symmetric polyarthritis is a characteristic feature of RA, making this option incorrect.
**Option B:** Morning stiffness lasting more than an hour is a common symptom of RA, so this option is also incorrect.
**Option C:** Systemic symptoms like fever, weight loss, and fatigue are associated with RA, making this option incorrect as well.

**Clinical Pearl / High-Yield Fact**
Rheumatoid arthritis often presents with a symmetric pattern of joint involvement, which is in contrast to other forms of arthritis like osteoarthritis, which typically affects weight-bearing joints.

**Correct Answer:** D.