The following drug is contraindicated in bronchial asthma :
**Core Concept**
The question revolves around the management of bronchial asthma, specifically the contraindication of certain medications. Bronchial asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, airflow limitation, and recurrent episodes of wheezing, coughing, and shortness of breath. The treatment of bronchial asthma involves avoiding triggers, using bronchodilators, and controlling inflammation.
**Why the Correct Answer is Right**
The correct answer is **Aspirin**. Aspirin is contraindicated in bronchial asthma due to its potential to trigger or worsen asthma symptoms. This is because aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the enzyme cyclooxygenase (COX), which leads to the production of leukotrienes and other pro-inflammatory mediators. These mediators can cause bronchospasm, exacerbating asthma symptoms.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because beta-2 agonists, such as salbutamol, are actually used as bronchodilators to relieve asthma symptoms.
**Option B:** This option is incorrect because corticosteroids, such as prednisolone, are actually used to control inflammation and prevent exacerbations in bronchial asthma.
**Option C:** This option is incorrect because antihistamines, such as chlorpheniramine, are not typically used to treat bronchial asthma and are not contraindicated.
**Clinical Pearl / High-Yield Fact**
Aspirin-exacerbated respiratory disease (AERD) is a condition where individuals with asthma experience severe asthma symptoms after ingesting aspirin or other NSAIDs. This is due to the inhibition of COX enzymes, leading to the production of leukotrienes and other pro-inflammatory mediators.
**Correct Answer:** A. Aspirin.