Which of the following drug will cause hyperophic pyloric stenosis is __________
**Core Concept**
Hyperophic pyloric stenosis (HPS) is a condition characterized by thickening of the pyloric muscle, leading to narrowing of the pyloric channel and gastric outlet obstruction. This condition is most commonly seen in infants, but can also occur in adults due to various medications or disease processes.
**Why the Correct Answer is Right**
Metoclopramide, a dopamine antagonist and prokinetic agent, is known to cause HPS as a rare but serious side effect. It works by blocking dopamine receptors in the gastrointestinal tract, leading to increased acetylcholine release and enhanced gastric motility. However, in some cases, this can cause an abnormal increase in pyloric muscle contraction, leading to hypertrophy and subsequent stenosis.
**Why Each Wrong Option is Incorrect**
* **Option A:** Omeprazole is a proton pump inhibitor (PPI) that reduces gastric acid production, and is not associated with HPS.
* **Option B:** Ranitidine is an H2 receptor antagonist that also reduces gastric acid production, and is not a known cause of HPS.
* **Option C:** Metronidazole is an antibiotic that is not associated with HPS.
**Clinical Pearl / High-Yield Fact**
Metoclopramide can cause HPS, especially in infants and young children, and should be used with caution in these populations.
**Correct Answer:** C. Metronidazole