**Core Concept**
The question revolves around the pharmacological properties and side effects of **pyrazinamide**, an essential drug in the treatment of **tuberculosis**. Pyrazinamide is a first-line antitubercular agent that works by inhibiting the growth of **Mycobacterium tuberculosis**. Understanding its side effects and interactions is crucial for effective and safe treatment.

**Why the Correct Answer is Right**
The correct answer, **A. One should discontinue treatment if hyperuricemia occurs**, is false because hyperuricemia, although a side effect of pyrazinamide, does not necessarily require discontinuation of the drug. Pyrazinamide can cause hyperuricemia by inhibiting the renal excretion of uric acid, but this condition is often managed with uricosuric agents or other measures rather than stopping the pyrazinamide. The drug's benefits in treating tuberculosis often outweigh the risks associated with hyperuricemia.

**Why Each Wrong Option is Incorrect**
**Option B:** This option is incorrect because it is true; there is minimal cross-resistance between pyrazinamide and **isoniazid (INH)**, making pyrazinamide effective against strains of M. tuberculosis resistant to INH.
**Option C:** This option is incorrect because polyarthralgia is indeed a side effect associated with pyrazinamide, related to its effect on uric acid levels.
**Option D:** This option is incorrect because it is true; pyrazinamide can cause **hepatotoxicity**, which is a significant side effect that requires monitoring during treatment.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that pyrazinamide is a crucial component of the initial phase of tuberculosis treatment due to its potent bactericidal effect against semi-dormant bacilli in acidic environments. Its side effects, including hepatotoxicity and hyperuricemia, must be carefully managed to ensure effective treatment.

**✓ Correct Answer: A. One should discontinue treatment if hyperuricemia occurs**