A person presents with acute poisoning, with chills and rigors similar to malaria. Most likely poisoning is with: AIIMS 06
**Core Concept**
The question is testing the student's knowledge of the clinical presentation of acute poisoning, specifically the mimicking of malaria symptoms such as chills and rigors. This requires an understanding of the pharmacological and physiological effects of certain toxins on the body.
**Why the Correct Answer is Right**
The correct answer is likely related to the use of certain toxins that can cause a "malaria-like" syndrome. One such toxin is **quinine**, which can cause chills, rigors, and fever similar to malaria. Quinine is a natural antimalarial drug that can be toxic in high doses, causing a range of systemic effects. The mechanism of quinine toxicity involves the inhibition of the sodium-potassium ATPase pump, leading to cellular depolarization and the release of histamine, which causes the symptoms of chills and rigors.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect as there is no direct association between this toxin and the clinical presentation of malaria-like symptoms.
* **Option B:** This option is incorrect as this toxin does not typically cause a malaria-like syndrome.
* **Option C:** This option is incorrect as this toxin is not known to cause chills and rigors similar to malaria.
**Clinical Pearl / High-Yield Fact**
In cases of suspected acute poisoning, it is essential to consider the patient's history, physical examination, and laboratory findings to narrow down the differential diagnosis. A high index of suspicion for certain toxins, such as quinine, can guide further investigation and management.
**Correct Answer: C. Quinine**