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176303 Unknown

A 40-year-old non-alcoholic male patient presented to the OPD with jaundice, lethargy, ahralgia, skin pigmentation, loss of libido, polyuria, polydipsia and exeional dyspnea. O/E, Hepatosplenomegaly Increased pigmentation and spider angiomas Ahropathy Ascites Loss of body hair and testicular atrophy Iron studies were done. LFTs were deranged and insulin levels were raised. Liver biopsy was also performed. Patient had no history of intake of any long-term medication. Iron studies are: – Plasma iron – 200 microgm/dL TIBC- 300 microgm/dL Transferrin saturation -90% Serum ferritin -5000 microgm/L Liver iron -10000 microgm/ gm of dry weight Hepatic iron index – 3 Which is the most common mutation seen in the above condition: –

AC282Y
BH63D
CH62D
DC283Y
Unknown
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176308 Pathology

True about apoptosis is all, except –

AConsiderable apoptosis may occur in tissues before it becomes apparent in histology
BApoptotic cells appear round mass of the intensely eosinophillic cytoplasm with dense nuclear chromatin fragments
CApoptosis of cells induce inflammatory reaction
DMacrophages phagocytose the apoptotic cells and degrade them.
Pathology
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