True about apoptosis is all, except –
**Core Concept**
Apoptosis is a regulated form of programmed cell death essential for eliminating damaged, unwanted, or excess cells in multicellular organisms. This process is crucial for maintaining tissue homeostasis, preventing cancer, and ensuring proper development.
**Why the Correct Answer is Right**
Apoptosis involves a series of cellular changes, including DNA fragmentation, membrane blebbing, and chromatin condensation. It is mediated by the intrinsic and extrinsic pathways, which converge on the caspase family of proteases. Key regulators of apoptosis include Bcl-2 family proteins, which control mitochondrial outer membrane permeabilization, and the tumor suppressor p53, which can induce apoptosis in response to DNA damage.
**Why Each Wrong Option is Incorrect**
* **Option A:** This statement is incorrect because apoptosis is not merely a passive process of cell death; it is a highly regulated and coordinated process involving multiple cellular and molecular mechanisms.
* **Option B:** This statement is incorrect because apoptosis is distinct from necrosis, which is an unregulated form of cell death characterized by cell lysis and inflammation.
* **Option C:** This statement is incorrect because the mitochondrial outer membrane permeabilization is a critical step in the intrinsic pathway of apoptosis, not a feature of apoptosis per se.
**Clinical Pearl / High-Yield Fact**
Apoptosis plays a crucial role in tissue development and maintenance, and its dysregulation is implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Understanding the mechanisms of apoptosis is essential for developing targeted therapies for these conditions.
**Correct Answer:**