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10380 Pathology
10382 Pathology

All of the following statement are true regarding silicosis, except:

ACrystalline forms are much more fibrogenic
BPhagocytosed silica crystals activate the inflammasome, leading to the release of inflammatory mediators, paicularly IL-2 and TNF (Correct Answer)
CAs the disease progresses, nodules coalesce into hard, collagenous scars
DHistologic examination reveals the hallmark lesion characterized by a central area of whorled collagen fibers with a more peripheral zone of dust-laden macrophages.