**Core Concept**
Nulliparity (never having given birth) and late menopause (menopause occurring at an older age) are associated with an increased risk of certain diseases due to prolonged exposure to estrogen. This prolonged exposure can stimulate the growth of certain types of breast and endometrial tissue, leading to an increased risk of cancer in these areas.

**Why the Correct Answer is Right**
The combination of nulliparity and late menopause is particularly concerning because it can lead to a prolonged period of estrogen dominance, which can stimulate the growth of estrogen receptor-positive (ER+) breast and endometrial tissue. This is because estrogen promotes the growth of these tissues, and prolonged exposure to estrogen can lead to uncontrolled cell division and cancer. The risk of endometrial cancer is also increased due to the prolonged exposure to estrogen, which can stimulate the growth of the endometrial lining, leading to hyperplasia and eventually cancer.

**Why Each Wrong Option is Incorrect**
* **Option B:** While obesity is a risk factor for endometrial cancer, it is not directly related to nulliparity and late menopause.
* **Option C:** Ovarian cancer is not directly related to nulliparity and late menopause, although there may be some indirect associations.
* **Option D:** Hypertension is not directly related to nulliparity and late menopause.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that prolonged exposure to estrogen can lead to an increased risk of estrogen receptor-positive breast and endometrial cancer. This is why women with a family history of breast or endometrial cancer, or those with a personal history of these cancers, may be advised to undergo regular screening and consider hormone replacement therapy (HRT) alternatives.

**Correct Answer: C. Ovarian cancer**