**Core Concept**
The question is testing the association of a rare genetic disorder characterized by premature sexual development, skeletal abnormalities, and multiple endocrine deficiencies. This condition is caused by a mutation in a specific gene that affects the development and function of multiple endocrine glands and bones.

**Why the Correct Answer is Right**
The correct answer is McCune-Albright Syndrome (MAS). MAS is a rare genetic disorder caused by a mutation in the GNAS1 gene, which encodes for the G protein alpha subunit. This mutation leads to excessive activity of the G protein, resulting in the development of multiple cystic bone lesions (fibrous dysplasia) and endocrinopathies, including precocious puberty, hyperthyroidism, and Cushing's syndrome. The condition is characterized by a classic triad of café-au-lait spots, polyostotic fibrous dysplasia, and endocrine dysfunction.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not match the classic triad of MAS.
**Option B:** This option is incorrect because it is not associated with the specific combination of sexual precocity, multiple cystic bone lesions, and endocrinopathies seen in MAS.
**Option C:** This option is incorrect because it does not accurately describe the genetic and clinical features of MAS.

**Clinical Pearl / High-Yield Fact**
MAS is a rare genetic disorder that should be considered in patients with a combination of premature sexual development, skeletal abnormalities, and multiple endocrine deficiencies. The classic triad of MAS (café-au-lait spots, polyostotic fibrous dysplasia, and endocrine dysfunction) is a useful diagnostic clue.

**Correct Answer:** D. McCune-Albright Syndrome