**Core Concept**
The management of opioid addiction involves a comprehensive approach, including medication-assisted treatment (MAT) to manage withdrawal symptoms, cravings, and prevent relapse. Long-term maintenance therapy is crucial to sustain recovery and prevent overdose.

**Why the Correct Answer is Right**
Methadone and buprenorphine are two commonly used medications for opioid use disorder (OUD) maintenance. Methadone is a full opioid agonist that helps reduce withdrawal symptoms and cravings, while buprenorphine is a partial opioid agonist with a ceiling effect, which reduces the risk of overdose. **Buprenorphine** is often preferred for long-term maintenance due to its ease of use, lower risk of diversion, and less potential for abuse compared to methadone.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because methadone is typically used for detoxification and short-term maintenance, not long-term maintenance.
* **Option B:** This option is incorrect because naltrexone is an opioid antagonist used for opioid detoxification and relapse prevention, but it is not suitable for long-term maintenance.
* **Option C:** This option is incorrect because clonidine is an alpha-2 adrenergic agonist used to manage opioid withdrawal symptoms, but it is not a medication for long-term maintenance.

**Clinical Pearl / High-Yield Fact**
When prescribing medications for opioid use disorder, it's essential to consider the patient's individual needs, medical history, and potential interactions with other medications to ensure effective treatment and minimize the risk of adverse effects.

**Correct Answer:** B. Buprenorphine