**Core Concept**
GLUT5 is a member of the facilitative glucose transporter family and plays a crucial role in the uptake of fructose in various tissues. It is expressed in the small intestine, liver, and adipose tissue, where it facilitates the absorption of dietary fructose.

**Why the Correct Answer is Right**
GLUT5 has a high affinity for fructose, allowing it to efficiently transport this sugar across cell membranes. In the small intestine, GLUT5 is responsible for the uptake of fructose from ingested food, while in the liver and adipose tissue, it facilitates the uptake of fructose from the bloodstream. This process is essential for maintaining normal blood glucose and lipid levels.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not accurately describe the primary location of GLUT5.
**Option B:** This option is incorrect as it does not specify the primary sugar transported by GLUT5.
**Option C:** This option is incorrect as it does not accurately describe the primary tissues expressing GLUT5.

**Clinical Pearl / High-Yield Fact**
GLUT5 is also known as SLC2A5 and is a fructose-specific glucose transporter that is upregulated in conditions of high fructose intake, such as obesity and type 2 diabetes.

**Correct Answer:** A. Small intestine, liver, and adipose tissue.