Lines of Sebileau pass through
**Core Concept**
Lines of Sebileau refer to a histopathological feature seen in certain skin conditions, particularly in psoriasis. They are characterized by the presence of thin, elongated cells that are aligned in a row, often perpendicular to the epidermal surface.
**Why the Correct Answer is Right**
The lines of Sebileau are formed due to the abnormal proliferation of keratinocytes in the epidermis, leading to an increase in the number of cells in the epidermal layer. This results in the formation of a row of elongated cells, which are then seen as lines of Sebileau under histological examination. The lines are thought to be a response to the abnormal keratinocyte proliferation, which is a hallmark of psoriasis.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because lines of Sebileau are not typically associated with conditions characterized by basal cell layer involvement, such as basal cell carcinoma.
* **Option B:** This option is incorrect because lines of Sebileau are not typically seen in conditions characterized by a diffuse infiltration of inflammatory cells, such as eczema.
* **Option C:** This option is incorrect because lines of Sebileau are not typically associated with conditions characterized by a thickening of the dermal layer, such as scleroderma.
**Clinical Pearl / High-Yield Fact**
Lines of Sebileau are a key histopathological feature of psoriasis, and their presence can help differentiate psoriasis from other skin conditions. Remember the mnemonic "Keratinocytes Gone Wild" to associate the abnormal proliferation of keratinocytes with the formation of lines of Sebileau.
**Correct Answer: D. Sebaceous glands**