**Core Concept**
The patient's symptoms of fresh bleed per rectum and abdominal pain, along with the findings of blood in the right colon and ileocecal valve on colonoscopy, suggest a possible case of lower gastrointestinal bleeding (LGIB) of obscure origin. This condition is characterized by recurrent or intermittent bleeding from the lower GI tract, often without an identifiable source on conventional endoscopic evaluation.

**Why the Correct Answer is Right**
In cases of LGIB of obscure origin, the next best step is to perform a **capsule endoscopy**. This involves swallowing a small capsule containing a camera that takes pictures of the inside of the GI tract as it passes through the body. Capsule endoscopy is particularly useful for visualizing the small intestine, which is a common site for obscure GI bleeding. The capsule can detect bleeding sites as small as 0.1 mm in diameter and can provide a detailed examination of the entire small intestine.

**Why Each Wrong Option is Incorrect**
**Option A:** **Intravenous Pyleography (IVP)** is an imaging test used to visualize the kidneys, ureters, and bladder. While it can be useful for detecting urinary tract abnormalities, it is not the best investigation for obscure GI bleeding.

**Option B:** **Computed Tomography (CT) Angiography** can be used to detect active bleeding in the GI tract, but it is not as sensitive as capsule endoscopy for detecting obscure bleeding sites.

**Option C:** **Upper GI series with barium study** is a radiographic examination of the upper GI tract, which is not relevant for investigating obscure bleeding from the lower GI tract.

**Clinical Pearl / High-Yield Fact**
In cases of LGIB of obscure origin, it's essential to remember that capsule endoscopy is more sensitive than push enteroscopy in detecting bleeding sites in the small intestine.

**Correct Answer:** C. Capsule endoscopy