**Core Concept**
Chronic viral hepatitis is a condition characterized by persistent infection with hepatitis viruses, leading to liver inflammation and potential progression to cirrhosis or hepatocellular carcinoma. The pathogenesis involves the interaction between the hepatitis virus and the host immune system.

**Why the Correct Answer is Right**
The correct answer is related to the immune response to hepatitis viruses, specifically the role of cytotoxic T lymphocytes (CTLs) in recognizing and eliminating infected hepatocytes. CTLs recognize viral antigens presented by major histocompatibility complex (MHC) class I molecules on the surface of infected cells, leading to their destruction. This process is crucial in controlling viral replication and preventing liver damage.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the immune response to hepatitis viruses. While B-cells do play a role in the immune response, their primary function is to produce antibodies, which are not directly involved in eliminating infected hepatocytes.
**Option B:** This option is incorrect because it is not a specific mechanism of immune response. The term "inflammation" is a general response to tissue damage, but it does not specifically describe the immune response to hepatitis viruses.
**Option C:** This option is incorrect because it is not a relevant mechanism of immune response in chronic viral hepatitis. While antiviral therapy may be used to treat chronic viral hepatitis, it is not a mechanism of immune response.

**Clinical Pearl / High-Yield Fact**
In chronic viral hepatitis, the development of liver fibrosis and cirrhosis is a result of the chronic immune response to the virus, leading to scarring and loss of liver function. This process can be accelerated by factors such as alcohol consumption, obesity, and metabolic syndrome.

**Correct Answer: D.**