If the first child is heterozygous and the wife is homozygous for an autosomal-recessive gene, what will be the outcome?
Correct Answer: 50% children affected, rest are carriers
Description: If the husband is heterozygous and the wife is homozygous for an autosomal recessive gene, 50% of the children will be affected; the rest will be carriers. This is pseudo-dominant inheritance, which refers to the observation of apparent dominant (parent to child) transmission of a known autosomal-recessive disorder, or it can also mean the inheritance of a recessive trait mimics a dominant pattern. This occurs when a homozygous affected individual has a paner who is a heterozygous carrier, and their children have 1 in 2 chance to get affected (50%) Ref: Nelson textbook of pediatrics 21st edition Pgno: 645
Category:
Pediatrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now