**Question:** Predisposing factors for Alzheimer's disease include all EXCEPT

A. Genetic factors
B. Environmental factors
C. Age
D. Lifestyle choices

**Core Concept:** Alzheimer's disease is a neurodegenerative disorder characterized by progressive memory loss, cognitive decline, and behavioral changes. Predisposing factors contribute to an increased risk of developing Alzheimer's disease. In this case, we are looking for factors that are NOT associated with the disease.

**Why the Correct Answer is Right:** Option D (Lifestyle choices) is the correct answer because lifestyle choices, including diet, exercise, and mental stimulation, have been shown to potentially reduce the risk of Alzheimer's disease. In contrast, genetic factors (Option A), environmental factors (Option B), and age (Option C) contribute to an increased risk of developing Alzheimer's disease.

**Why Each Wrong Option is Incorrect:**

A. Genetic factors: Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes are associated with early-onset familial Alzheimer's disease. Genetic factors play a role in Alzheimer's disease development.

B. Environmental factors: Pollutants, head injuries, and certain infections have been linked to an increased risk of Alzheimer's disease. While certain environmental factors can contribute to Alzheimer's development, the question specifically mentions "all EXCEPT," indicating that environmental factors are still relevant but not the focus of this answer.

C. Age: Alzheimer's disease is a common cause of dementia in older adults. Age is a risk factor for Alzheimer's disease, as the disease is more common in individuals over the age of 65 years.

**Clinical Pearl:** Lifestyle choices play a crucial role in Alzheimer's disease prevention, emphasizing the importance of maintaining a healthy lifestyle. Age, genetic factors, and environmental factors contribute to Alzheimer's disease risk, while paying attention to lifestyle choices can potentially reduce the risk.

**Correct Answer:** Lifestyle choices (Option D) are not mentioned in the question's focus on "all EXCEPT." While certain lifestyle factors can influence Alzheimer's development, the main point is that these options (Age, Genetic factors, and Environmental factors) contribute to Alzheimer's risk, while lifestyle choices can help reduce the risk.